So after the last post, an going out to dinner, I started reading up on the Yahoo Group for the BaoFeng UV-5R series, they point to a site I found last night and read through.
Turns out that with the chip in the USB to serial cable (chip built in to USB Plug), you have to use the right driver. I had the newer driver 3.4 something, and it would transmit at random. I down graded to the 184.108.40.206 driver, and I haven't had it try to transmit yet.
So if you're having problems with random transmitting when you're trying to program your BaoFeng UV-5R or other, check your driver make sure you're using the right one.